Walter博士是一个很简单的人并拥有很大的愿望，为了愿望，他会做什么？

A simple man, Dr. Walter Newman, has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctors loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?

An obsessed doctor tries to cure human deformities through DNA splicing, an obsession drawing him into a dark world where he experiments on the patients at Edgewood Asylum. Ignoring his pregnant wife, Olivia, she comes to see him one night, but everything goes horribly wrong as Dr. Newman watches in horror as Olivia delivers their twins - One twin is a beautiful baby girl, the other a deformed creature that defies nature. 28 years later, on a dark road, a van breaks down. Young, beautiful Liz Holliman of the Roslyn Center for the Deaf is traveling with a group of young teens and her driver, ex-con Jeff Thomas. With a flat tire, a storm, and freezing temperatures, they must seek shelter. The group make their way to an old abandoned building -- the Edgewood Asylum. Little do they know, evil awaits them ...